Plakophilin 2 anticorps (C-Term)

N° du produit ABIN3042556

Cet anticorps Lapin Polyclonal détecte spécifiquement Plakophilin 2 dans WB. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour Plakophilin 2 anticorps (C-Term) (ABIN3042556)

Antigène: Plakophilin 2 (PKP2)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Plakophilin 2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Plakophilin 2 anticorps

Épitope: AA 863-881, C-Term

Fonction: Anti-Plakophilin 2/PKP2 Antibody Picoband®

Séquence: KKTDFVNSRT AKAYHSLKD

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Plakophilin 2/PKP2 Antibody (ABIN3042556). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Plakophilin 2, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1 "Entrez Gene: PKP2 plakophilin 2" 2 Marcus, F. I., Fontaine, G. H., Guiraudon, G., Frank, R., Laurenceau, J. L., Malergue, C., Grosgogeat, Y. Right ventricular dysplasia: a report of 24 adult cases. Circulation 65: 384-398, 1982. 3 Mertens C, Kuhn C, Franke WW (Jan 1997). "Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque". J Cell Biol 135 (4): 1009-25.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Plakophilin 2

Antigène: Plakophilin 2 (PKP2)

Autre désignation: PKP2

Sujet:

Synonyms: Plakophilin-2,PKP2,

Tissue Specificity: Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata. .

Background: Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. It is mapped to 12p11.21. PKP2 is a constituent of the desmosomal plaque in simple epithelia, some stratified epithelia, and some nonepithelial cells. PKP2 is also enriched in the karyoplasm of cells of various types, including those lacking desmosomes. Plakophilin proteins participate in linking cadherins to intermediate filaments in the cytoskeleton and this gene product may regulate the signaling activity of beta-catenin. PKP2 has been shown to interact with Desmoplakin, Plakoglobin and Desmoglein 1.

Sequence Similarities: Belongs to the beta-catenin family.

Poids moléculaire: 97 kDa

UniProt: Q99959

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2